![]() Moderate to Severe Polyarticular Juvenile Rheumatoid Arthritis (May 1999).Moderate to Severe Rheumatoid Arthritis (RA) (Nov 1998).In the United States, etanercept is indicated for: It is on the World Health Organization's List of Essential Medicines. It is a large molecule, with a molecular weight of 150 kDa, that binds to TNFα and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNFα. These investigators also patented the protein, selling all rights to its use to Immunex, a biotechnology company that was acquired by Amgen in 2002. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and his colleagues. The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for blockade of TNF in vivo in the early 1990s by Bruce A. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc. Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor-alpha. It fuses the TNF receptor to the constant end of the IgG1 antibody. Įtanercept is a fusion protein produced by recombinant DNA. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha. ![]() Autoimmune diseases are caused by an overactive immune response. Tumor necrosis factor alpha (TNFα) is the "master regulator" of the inflammatory (immune) response in many organ systems. ![]() Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. ![]() Enbrel is original drugs and others may be first copies not exact copies.Etanercept, sold under the brand name Enbrel among others, is a biologic medical product that is used to treat autoimmune diseases by interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF inhibitor. Confusing ?īasically generic versions of Enbrel or biologic injections do work but they are not exactly same drugs. That is why generic versions of biologics are not called generics, but biosimilars, meaning they are not exactly alike but similar. Its easy to copy a house architecture, but very complex to copy whole building in exactly same way. Chemical composition wise simple tablets like a simple house, while biologic injections are like whole building. If you take it every 12 weeks, cost per year ~ 4 lakhsīut some times you can extend it upto 16 weeks, cost per year ~īut generic version of biologic medicines like Enbrel are not same like generic versions of a tablet like paracetamol etc. Given every 8weeks in a saline drip (but in non affording patients can be stretched to 12 weeks. Infimab (sun pharma) - Biosimilar molecule Remicade (Janssen pharma brand) - Original biologic molecule There are other biologic injections which should also be considered #Intacept 50 mg injection price free#There are generic versions of Enbrel like Etacept by cipla and Intacept by Intas which are similar price but company might throw additional free injections making overall monthly cost cheaper. The earlier one starts proper gout meds and longer you take your meds properly, with target uric acid being maintained, the lesser you will have to worry about having so much if’s and but’s on eating chickenĮnbrel if given 50 mg a week can cost around 12000 - 16000 per week, around 50000 per month, depending on whether you are enrolled for any patient support program or not. Keep your attack pills handy (your doctor might have given you them) for those ‘binge on chicken’ days where you really can’t control and push your uric acid off the edge Avoid having meat during really bad attacks and until you reasonably control your goutĤ. ![]() Avoid gravies, creams etc (which increase the fat and offset the good effect)ģ. Prefer skinless and boneless breast (the whiter part). Most important, take meds (because gout risk is partially genetic) and keep uric acid below 6mg/dl (monitor 2–3 monthly at least)Ģ. Also fried chicken is bad for health for gout patients, not only because it’s chicken, but more because it’s fried Remember skin, legs and drumstick contains more fat and/or purines. As along as you are having it in limited quantity and taking your medicines well and keeping uric acid below 6.Ĭhicken is considered a relatively healthy meat especially and skinless boneless breast part of it. ![]()
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